Randomized Controlled Trial of Preconception Interventions in Infertile Women With Polycystic Ovary Syndrome.

ABSTRACT:

Context

Lifestyle modification is recommended in women with polycystic ovary syndrome (PCOS) prior to conception but there are few randomized trials to support its implementation or benefit.

Objective

This study aimed to determine the relative efficacy of preconception intervention on reproductive and metabolic abnormalities in overweight/obese women with PCOS.

Design, setting, and participants

This was a randomized controlled trial of preconception and infertility treatment at Academic Health Centers in women with infertility due to PCOS, age 18-40 y and body mass index 27-42 kg/m(2).

Intervention

Women were randomly assigned to receive either 16 weeks of 1) continuous oral contraceptive pills (OCPs) (ethinyl estradiol 20 mcg/1 mg norethindrone acetate) ("OCP"

SUBMITTER: Legro RS 

PROVIDER: S-EPMC4702450 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature