Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women.

ABSTRACT:

Context

Obesity is associated with a pro-inflammatory state and relative hypogonadotropic hypogonadism. Estrogen (E2) is a potential link between these phenomena because it exhibits negative feedback on gonadotropin secretion and also inhibits production of pro-inflammatory cytokines.

Objective

We sought to examine the effect of estrogen priming on the hypothalamic-pituitary-ovarian axis in obesity.

Design, setting, and participants

This was an interventional study at an academic center of 11 obese and 10 normal-weight (NW) women.

Intervention

A frequent blood-sampling study and one month of daily urinary collection were performed before and after administration of transdermal estradiol 0.1 mg/d for one entire menstrual cycle.

Main outcome measures

Serum

SUBMITTER: Al-Safi ZA 

PROVIDER: S-EPMC4702462 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature