The Impact of Prenatal Ethanol Exposure on Neuroanatomical and Behavioral Development in Mice.

ABSTRACT:

Background

In utero alcohol, or ethanol (EtOH), exposure produces developmental abnormalities in the brain of the fetus, which can result in lifelong behavioral abnormalities. Fetal alcohol spectrum disorders (FASD) is a term used to describe a range of adverse developmental conditions caused by EtOH exposure during gestation. Children diagnosed with FASD potentially exhibit a host of phenotypes including growth retardation, facial dysmorphology, central nervous system anomalies, abnormal behavior, and cognitive deficits. Previous research suggests that abnormal gene expression and circuitry in the neocortex may underlie reported disabilities of learning, memory, and behavior resulting from early exposure to alcohol (J Neurosci, 33, 2013, 18893).

Methods

Here, we utilize a m

SUBMITTER: Abbott CW 

PROVIDER: S-EPMC4702517 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature