Conditional Immune Escape during Chronic Simian Immunodeficiency Virus Infection.

ABSTRACT:

Unlabelled

Anti-HIV CD8 T cells included in therapeutic treatments will need to target epitopes that do not accumulate escape mutations. Identifying the epitopes that do not accumulate variants but retain immunogenicity depends on both host major histocompatibility complex (MHC) genetics and the likelihood for an epitope to tolerate variation. We previously found that immune escape during acute SIV infection is conditional; the accumulation of mutations in T cell epitopes is limited, and the rate of accumulation depends on the number of epitopes being targeted. We have now tested the hypothesis that conditional immune escape extends into chronic SIV infection and that epitopes with a preserved wild-type sequence have the potential to elicit epitope-specific CD8 T cells. We deep seq

SUBMITTER: Gellerup DD 

PROVIDER: S-EPMC4702533 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature