TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling.

ABSTRACT:

Unlabelled

Host restriction factor TRIM5 inhibits retroviral transduction in a species-specific manner by binding to and destabilizing the retroviral capsid lattice before reverse transcription is completed. However, the restriction mechanism may not be that simple since TRIM5 E3 ubiquitin ligase activity, the proteasome, autophagy, and TAK1-dependent AP-1 signaling have been suggested to contribute to restriction. Here, we show that, among a panel of seven primate and Carnivora TRIM5 orthologues, each of which has potential for potent retroviral restriction activity, all activated AP-1 signaling. In contrast, TRIM family paralogues most closely related to TRIM5 did not. While each primate species has a single TRIM5 gene, mice have at least seven TRIM5 homologues that cluster into

SUBMITTER: Lascano J 

PROVIDER: S-EPMC4702541 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature