UET: a database of evolutionarily-predicted functional determinants of protein sequences that cluster as functional sites in protein structures.

ABSTRACT: The structure and function of proteins underlie most aspects of biology and their mutational perturbations often cause disease. To identify the molecular determinants of function as well as targets for drugs, it is central to characterize the important residues and how they cluster to form functional sites. The Evolutionary Trace (ET) achieves this by ranking the functional and structural importance of the protein sequence positions. ET uses evolutionary distances to estimate functional distances and correlates genotype variations with those in the fitness phenotype. Thus, ET ranks are worse for sequence positions that vary among evolutionarily closer homologs but better for positions that vary mostly among distant homologs. This approach identifies functional determinants, predicts functi

SUBMITTER: Lua RC 

PROVIDER: S-EPMC4702906 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature