Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues.

ABSTRACT: It is unclear how the immune response in early life becomes appropriately stimulated to provide protection while also avoiding excessive activation as a result of diverse new antigens. T cells are integral to adaptive immunity; mouse studies indicate that tissue localization of T cell subsets is important for both protective immunity and immunoregulation. In humans, however, the early development and function of T cells in tissues remain unexplored. We present here an analysis of lymphoid and mucosal tissue T cells derived from pediatric organ donors in the first two years of life, as compared to adult organ donors, revealing early compartmentalization of T cell differentiation and regulation. Whereas adult tissues contain a predominance of memory T cells, in pediatric blood and tissues th

SUBMITTER: Thome JJ 

PROVIDER: S-EPMC4703455 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature