Longitudinal changes of amygdala and default mode activation in adolescents prenatally exposed to cocaine.

ABSTRACT: Prenatal cocaine exposure (PCE) is associated with long-term and negative effect on arousal regulation. Recent neuroimaging studies have examined brain mechanisms related to arousal dysregulation with cross-sectional experimental designs; but longitudinal changes in the brain, reflecting group differences in neurodevelopment, have never been directly examined. To directly assess the interaction of PCE and neurodevelopment, the present study used a longitudinal design to analyze functional magnetic resonance imaging (fMRI) data collected from 33 adolescents (21 with PCE and 12 non-exposed controls) while they performed the same working memory task with emotional distracters at two points in time. The mean age of participants was 14.3 years at time_1 and 16.7 years at time_2. With confoundin

SUBMITTER: Li Z 

PROVIDER: S-EPMC4703494 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature