Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.

ABSTRACT: Cytotoxic therapies prime adaptive immune responses to cancer by stimulating the release of tumor-associated antigens. However, the tumor microenvironment into which these antigens are released is typically immunosuppressed, blunting the ability to initiate immune responses. Recently, activation of the DNA sensor molecule STING by cyclic dinucleotides was shown to stimulate infection-related inflammatory pathways in tumors. In this study, we report that the inflammatory pathways activated by STING ligands generate a powerful adjuvant activity for enhancing adaptive immune responses to tumor antigens released by radiotherapy. In a murine model of pancreatic cancer, we showed that combining CT-guided radiotherapy with a novel ligand of murine and human STING could synergize to control local

SUBMITTER: Baird JR 

PROVIDER: S-EPMC4703500 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature