Regulation of complement-dependent cytotoxicity by TGF-β-induced epithelial-mesenchymal transition.

ABSTRACT: The process of epithelial-mesenchymal transition (EMT), in addition to being an initiating event for tumor metastasis, is implicated in conferring several clinically relevant properties to disseminating cancer cells. These include stem cell-like properties, resistance to targeted therapies and ability to evade immune surveillance. Enrichment analysis of gene expression changes during transforming growth factor-β (TGF-β)-induced EMT in lung cancer cells identified complement cascade as one of the significantly enriched pathway. Further analysis of the genes in the complement pathway revealed an increase in the expression of complement inhibitors and a decrease in the expression of proteins essential for complement activity. In this study, we tested whether EMT confers resistance to compleme

SUBMITTER: Goswami MT 

PROVIDER: S-EPMC4703565 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature