Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study.

ABSTRACT:

Study question

Is oral contraceptive use around the time of pregnancy onset associated with an increased risk of major birth defects?

Methods

In a prospective observational cohort study, data on oral contraceptive use and major birth defects were collected among 880,694 live births from Danish registries between 1997 and 2011. We conservatively assumed that oral contraceptive exposure lasted up to the most recently filled prescription. The main outcome measure was the number of major birth defects throughout one year follow-up (defined according to the European Surveillance of Congenital Anomalies classification). Logistic regression estimated prevalence odds ratios of any major birth defect as well as categories of birth defect subgroups.

Study answer and limitations

SUBMITTER: Charlton BM 

PROVIDER: S-EPMC4703703 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature