EBF2 promotes the recruitment of beige adipocytes in white adipose tissue.

ABSTRACT:

Objective

The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals. The helix-loop-helix transcription factor Early B-Cell Factor-2 (EBF2) regulates brown adipose tissue development. Here, we asked if EBF2 regulates beige fat cell biogenesis and protects animals against obesity.

Methods

In addition to primary cell culture studies, we used ​Ebf2 knockout mice and mice overexpressing EBF2 in the adipose tissue to study the necessity and sufficiency of EBF2 to induce beiging in vivo.

Results

We found that EBF2 is required for beige adipocyte development in mice. Subcutaneous WAT or primary adipose cell cultures from Ebf2 knockout mice did not induce Uncou

SUBMITTER: Stine RR 

PROVIDER: S-EPMC4703852 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature