Ontology highlight
ABSTRACT:
SUBMITTER: Herter JM
PROVIDER: S-EPMC4703868 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Herter Jan M JM Grabie Nir N Cullere Xavier X Azcutia Veronica V Rosetti Florencia F Bennett Paul P Herter-Sprie Grit S GS Elyaman Wassim W Luscinskas Francis W FW Lichtman Andrew H AH Mayadas Tanya N TN
Nature communications 20151218
The mechanisms driving T cell homing to lymph nodes and migration to tissue are well described but little is known about factors that affect T cell egress from tissues. Here, we generate mice with a T cell-specific deletion of the scaffold protein A kinase anchoring protein 9 (AKAP9) and use models of inflammatory disease to demonstrate that AKAP9 is dispensable for T cell priming and migration into tissues and lymph nodes, but is required for T cell retention in tissues. AKAP9 deficiency result ...[more]