Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate.

ABSTRACT: Fate determination in the mammalian telencephalon, with its diversity of neuronal subtypes and relevance to neuropsychiatric disease, remains a critical area of study in neuroscience. Most studies investigating this topic focus on the diversity of neural progenitors within spatial and temporal domains along the lateral ventricles. Often overlooked is whether the location of neurogenesis within a fate-restricted domain is associated with, or instructive for, distinct neuronal fates. Here, we use in vivo fate mapping and the manipulation of neurogenic location to demonstrate that apical versus basal neurogenesis influences the fate determination of major subgroups of cortical interneurons derived from the subcortical telencephalon. Somatostatin-expressing interneurons arise mainly from apica

SUBMITTER: Petros TJ 

PROVIDER: S-EPMC4704102 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature