FosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin.

ABSTRACT: In this work, we demonstrate that the fosI gene encodes a predicted small protein with 134 amino acids and determines reduced susceptibility to fosfomycin. It raised the MIC from 0.125 to 6 μg/ml when the pBRA100 plasmid was introduced into Escherichia coli TOP10 and to 16 μg/ml when the gene was cloned into the pBC_SK(-) vector and expressed in E. coli TOP10.

SUBMITTER: Pelegrino Kde O 

PROVIDER: S-EPMC4704179 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature