Bone marrow stem cell dysfunction in radiation-induced abscopal bone loss.

ABSTRACT:

Background

Bone-related complications are commonly reported in cancer patients receiving radiotherapy and are collectively referred to as the abscopal effect of irradiation, the mechanism of which remains poorly understood. When patients receive targeted radiotherapy to a tumor, the local skeleton is exposed to radiation, particularly within the bone marrow. We therefore investigated the hypothesis that single bone irradiation can induce deterioration of the skeleton outside the radiation field and is mediated by the bone marrow.

Methods

Using 4-month-old male Sprague-Dawley rats, the effects of irradiation (20 Gy, right distal femur and proximal tibia) on bone quality, microarchitecture and bone marrow, were evaluated prospectively by microcomputed tomography, histomorphome

SUBMITTER: Zou Q 

PROVIDER: S-EPMC4704383 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature