Maternal characteristics and mid-pregnancy serum biomarkers as risk factors for subtypes of preterm birth.

ABSTRACT:

Objective

To examine the relationship between maternal characteristics, serum biomarkers and preterm birth (PTB) by spontaneous and medically indicated subtypes.

Design

Population-based cohort.

Setting

California, United States of America.

Population

From a total population of 1 004 039 live singleton births in 2009 and 2010, 841 665 pregnancies with linked birth certificate and hospital discharge records were included.

Methods

Characteristics were compared for term and preterm deliveries by PTB subtype using logistic regression and odds ratios adjusted for maternal characteristics and obstetric factors present in final stepwise models and 95% confidence intervals. First-trimester and second-trimester serum marker levels were analysed in a subset of 125 

SUBMITTER: Jelliffe-Pawlowski LL 

PROVIDER: S-EPMC4704442 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature