Preclinical mouse models for assessing axial compression of long bones during exercise.

ABSTRACT: The aim of this laboratory method is to describe two approaches for the investigation of bone responses to mechanical loading in mice in vivo. The first is running exercise, because it is easily translatable clinically, and the second is axial compression of the tibia, because it is precisely controllable. The effects of running exercise, and in general physical activity, on bone tissue have been shown to be both direct through mechanical loading (ground impact and muscle tension) and indirect through metabolic changes. Therefore, running exercise has been considered the most convenient preclinical model for demonstrating the general idea that exercise is good for bone health, either early in age for increasing peak bone mass or later in age by slowing down bone loss. However, numerous com

SUBMITTER: Stadelmann VA 

PROVIDER: S-EPMC4704463 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature