Ipsilateral deficits of dopaminergic neurotransmission in Parkinson's disease.

ABSTRACT:

Objective

The nigral lesion and the resulting contralateral motor signs of Parkinson's disease (PD) are remarkably asymmetric. This study investigated the prevalence of patients with "wrong-sided" lesions, that is, patients with symptoms on the side ipsilateral to the predominant dopaminergic nigrostriatal deficit.

Methods

The analyzed sample included 434 early unmedicated PD patients from the Parkinson's Progression Markers Initiative database. Asymmetry indices of motor function and putamen [(123)I]FP-CIT SPECT were calculated from the screening visit data.

Results

Ipsilateral deficits were unexpectedly common even when only patients with clear motor and dopaminergic asymmetries were included in the analysis (8.1%, n = 24/295). When patients with any asymmetry were

SUBMITTER: Kaasinen V 

PROVIDER: S-EPMC4704477 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature