A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.

ABSTRACT: A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25C₂H₅OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.

SUBMITTER: Sandhaus S 

PROVIDER: S-EPMC4704796 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature