Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits.

ABSTRACT: It has been suggested that pharmacogenomic phenotypes are influenced by genetic variants with larger effect sizes than other phenotypes, such as complex disease risk. This is presumed to reflect the fact that relevant environmental factors (drug exposure) are appropriately measured and taken into account. To test this hypothesis, we performed a systematic comparison of effect sizes between pharmacogenomic and non-pharmacogenomic phenotypes across all genome-wide association studies (GWAS) reported in the NHGRI GWAS catalog. We found significantly larger effect sizes for studies focused on pharmacogenomic phenotypes, as compared with complex disease risk, morphological phenotypes and endophenotypes. We found no significant differences in effect sizes between pharmacogenomic studies focused

SUBMITTER: Maranville JC 

PROVIDER: S-EPMC4704992 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature