Vaccinations and childhood type 1 diabetes mellitus: a meta-analysis of observational studies.

ABSTRACT:

Aims/hypothesis

The aim of this study was to investigate the association between routine vaccinations and the risk of childhood type 1 diabetes mellitus by systematically reviewing the published literature and performing meta-analyses where possible.

Methods

A comprehensive literature search was performed of MEDLINE and EMBASE to identify all studies that compared vaccination rates in children who subsequently developed type 1 diabetes mellitus and in control children. ORs and 95% CIs were obtained from published reports or derived from individual patient data and then combined using a random effects meta-analysis.

Results

In total, 23 studies investigating 16 vaccinations met the inclusion criteria. Eleven of these contributed to meta-analyses which included data fro

SUBMITTER: Morgan E 

PROVIDER: S-EPMC4705121 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature