Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.

ABSTRACT:

Purpose

Women with human papilloma virus (HPV)-associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i) identify high-risk HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same patients and (ii) determine if these HPVs were biologically active.

Methods

A range of polymerase chain reaction and immunohistochemical techniques were used to conduct a retrospective cohort study of cervical precancers and subsequent breast cancers in the same patients.

Results

The same high-risk HPV types were identified in both the cervical and breast specimens in 13 (46%) of 28 patients. HPV type 18 was the most prevalent. HPVs appeared to be biologically

SUBMITTER: Lawson JS 

PROVIDER: S-EPMC4705232 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature