Pathogenesis of experimental salmonid alphavirus infection in vivo: an ultrastructural insight.

ABSTRACT: Salmonid alphavirus (SAV) is an enveloped, single-stranded, positive sense RNA virus belonging to the family Togaviridae. It causes economically devastating disease in cultured salmonids. The characteristic features of SAV infection include severe histopathological changes in the heart, pancreas and skeletal muscles of diseased fish. Although the presence of virus has been reported in a wider range of tissues, the mechanisms responsible for viral tissue tropism and for lesion development during the disease are not clearly described or understood. Previously, we have described membrane-dependent morphogenesis of SAV and associated apoptosis-mediated cell death in vitro. The aims of the present study were to explore ultrastructural changes associated with SAV infection in vivo. Cytolytic cha

SUBMITTER: Herath TK 

PROVIDER: S-EPMC4705579 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature