Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance.

ABSTRACT: Recent major advances in understanding the molecular basis of acute myeloid leukemia (AML) provide a double-edged sword. Although defining the topology and key features of the molecular landscape are fundamental to development of novel treatment approaches and provide opportunities for greater individualization of therapy, confirmation of the genetic complexity presents a huge challenge to successful translation into routine clinical practice. It is now clear that many genes are recurrently mutated in AML; moreover, individual leukemias harbor multiple mutations and are potentially composed of subclones with differing mutational composition, rendering each patient's AML genetically unique. In order to make sense of the overwhelming mutational data and capitalize on this clinically, it is i

SUBMITTER: Grimwade D 

PROVIDER: S-EPMC4705608 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature