Identification of novel gene and pathway targets for human epilepsy treatment.

ABSTRACT:

Background

The aim of this study was to explore epilepsy-related mechanism so as to figure out the possible targets for epilepsy treatment.

Methods

The gene expression profile dataset GES32534 was downloaded from Gene Expression Omnibus database. We identified the differentially expressed genes (DEGs) by Affy package. Then the DEGs were used to perform gene ontology (GO) and pathway enrichment analyses. Furthermore, a protein-protein interaction (PPI) network was constructed with the DEGs followed by co-expression modules construction and analysis.

Results

Total 420 DEGs were screened out, including 214 up-regulated and 206 down-regulated genes. Functional enrichment analysis revealed that down-regulated genes were mainly involved in the process of immunity regulation

SUBMITTER: Jin Y 

PROVIDER: S-EPMC4705636 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature