MMB-GUI: a fast morphing method demonstrates a possible ribosomal tRNA translocation trajectory.

ABSTRACT: Easy-to-use macromolecular viewers, such as UCSF Chimera, are a standard tool in structural biology. They allow rendering and performing geometric operations on large complexes, such as viruses and ribosomes. Dynamical simulation codes enable modeling of conformational changes, but may require considerable time and many CPUs. There is an unmet demand from structural and molecular biologists for software in the middle ground, which would allow visualization combined with quick and interactive modeling of conformational changes, even of large complexes. This motivates MMB-GUI. MMB uses an internal-coordinate, multiscale approach, yielding as much as a 2000-fold speedup over conventional simulation methods. We use Chimera as an interactive graphical interface to control MMB. We show how this

SUBMITTER: Tek A 

PROVIDER: S-EPMC4705676 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature