The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.

ABSTRACT: Groucho (Gro) is a Drosophila co-repressor that regulates the expression of a large number of genes, many of which are involved in developmental control. Previous studies have shown that its central region is essential for function even though its three domains are poorly conserved and intrinsically disordered. Using these disordered domains as affinity reagents, we have now identified multiple embryonic Gro-interacting proteins. The interactors include protein complexes involved in chromosome organization, mRNA processing, and signaling. Further investigation of the interacting proteins using a reporter assay showed that many of them modulate Gro-mediated repression either positively or negatively. The positive regulators include components of the spliceosomal subcomplex U1 small nuclear

SUBMITTER: Kwong PN 

PROVIDER: S-EPMC4705979 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature