Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.

ABSTRACT:

Background

We conducted a genomewide association study (GWAS) for maximum number of alcoholic drinks consumed in a 24-hour period ("MaxDrinks"), in 2 independent samples comprised of over 9,500 subjects, following up on our GWAS for alcohol dependence (AD) in European Americans (EAs) and African Americans (AAs).

Methods

The samples included our GWAS samples (Yale-UPenn) recruited for studies of the genetics of drug or AD, and a publicly available sample: the Study of Addiction: Genetics and Environment (SAGE). Genomewide association analysis was performed for ~890,000 single nucleotide polymorphisms (SNPs) using linear association random effects models. EAs and AAs were separately analyzed.

Results

The results confirmed significant associations of the well-known funct

SUBMITTER: Xu K 

PROVIDER: S-EPMC4706077 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature