Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry.

ABSTRACT: The identification of extracellular vesicles (EVs) as intercellular conveyors of biological information has recently emerged as a novel paradigm in signaling, leading to the exploitation of EVs and their contents as biomarkers of various diseases. However, whether there are diurnal variations in the size, number, and tissue of origin of blood EVs is currently not known, and could have significant implications when using EVs as biomarkers for disease progression. Currently available technologies for the measurement of EV size and number are either time consuming, require specialized equipment, or lack sufficient accuracy across a range of EV sizes. Flow cytometry represents an attractive alternative to these methods; however, traditional flow cytometers are only capable of measuring particl

SUBMITTER: Danielson KM 

PROVIDER: S-EPMC4706300 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature