Accelerated Restoration of Ocular Surface Health in Dry Eye Disease by Self-Retained Cryopreserved Amniotic Membrane.

ABSTRACT:

Purpose

To evaluate the clinical efficacy of self-retained cryopreserved amniotic membrane in treating dry eye disease.

Methods

Retrospective review of 10 patients treated with self-retained cryopreserved amniotic membrane (PROKERA® Slim [PKS], Bio-Tissue, Miami, FL) for moderate-to-severe dry eye refractory to conventional maximal medical treatments. Patients' symptoms, use of medications, conjunctival inflammation, corneal staining, and visual acuity were compared before and after treatment.

Results

PKS was placed in 15 eyes of the 10 patients for 4.9 ± 1.5 days. All patients experienced symptomatic relief for a period of 4.2 ± 4.7 months (P<.001). Such improvement was accompanied by reduction of OSDI scores (P<.001), use of topical medications (P<.001), conjunctiva

SUBMITTER: Cheng AM 

PROVIDER: S-EPMC4706470 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature