Symptomatic Respiratory Virus Infection and Chronic Lung Allograft Dysfunction.

ABSTRACT:

Background

Chronic lung allograft dysfunction (CLAD) is a major cause of allograft loss post-lung transplantation. Prior studies have examined the association between respiratory virus infection (RVI) and CLAD were limited by older diagnostic techniques, study design, and case numbers. We examined the association between symptomatic RVI and CLAD using modern diagnostic techniques in a large contemporary cohort of lung transplant recipients (LTRs).

Methods

We retrospectively assessed clinical variables including acute rejection, cytomegalovirus pneumonia, upper and lower RVI, and the primary endpoint of CLAD (determined by 2 independent reviewers) in 250 LTRs in a single university transplantation program. Univariate and multivariate Cox models were used to analyze the relati

SUBMITTER: Fisher CE 

PROVIDER: S-EPMC4706632 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature