The Impact of Enhanced Screening and Treatment on Hepatitis C in the United States.

ABSTRACT:

Background

The effectiveness of interferon-free direct-acting antivirals (DAA) in treating chronic hepatitis C virus (HCV) is limited by low screening and treatment rates, particularly among people who inject drugs (PWIDs).

Methods

To evaluate the levels of screening and treatment with interferon-free DAAs that are required to control HCV incidence and HCV-associated morbidity and mortality, we developed a transmission model, stratified by age and by injection drug use, and calibrated it to epidemiological data in the United States from 1992 to 2014. We quantified the impact of administration of DAAs at current and at enhanced screening and treatment rates, focusing on outcomes of HCV incidence, prevalence, compensated and decompensated cirrhosis, hepatocellular carcinoma, l

SUBMITTER: Durham DP 

PROVIDER: S-EPMC4706637 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature