Genetic studies of Polish migraine patients: screening for causative mutations in four migraine-associated genes.

ABSTRACT:

Background and aim

Migraine is the most common neurological disorder, affecting approximately 12 % of the adult population worldwide, caused by both environmental and genetic factors. Three causative genes have been identified in familial hemiplegic migraine (FHM) families: CACNA1A, ATP1A2, and SCNA1A. Recently, several mutations in KCNK18 have also been found as causative factors in migraine development. The aim of our study was to identify the genetic background of migraine in the Polish population.

Material and methods

Sixty patients with migraine without aura (MO) or with different types of migraine with aura (MA), including sporadic hemiplegic, familial hemiplegic, and probable familial hemiplegic, were screened for mutations in the four genes previously linked with dif

SUBMITTER: Domitrz I 

PROVIDER: S-EPMC4706665 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature