Evaluating the performance of selection scans to detect selective sweeps in domestic dogs.

ABSTRACT: Selective breeding of dogs has resulted in repeated artificial selection on breed-specific morphological phenotypes. A number of quantitative trait loci associated with these phenotypes have been identified in genetic mapping studies. We analysed the population genomic signatures observed around the causal mutations for 12 of these loci in 25 dog breeds, for which we genotyped 25 individuals in each breed. By measuring the population frequencies of the causal mutations in each breed, we identified those breeds in which specific mutations most likely experienced positive selection. These instances were then used as positive controls for assessing the performance of popular statistics to detect selection from population genomic data. We found that artificial selection during dog domesticatio

SUBMITTER: Schlamp F 

PROVIDER: S-EPMC4706764 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature