ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer.

ABSTRACT: Colorectal cancer is one of the leading causes of cancer mortality in Western civilization. Studies have shown that colorectal cancer arises as a consequence of the modification of genes that regulate important cellular functions. Deregulation of the WNT and RAS/MAPK/PI3K signaling pathways has been shown to be important in the early stages of colorectal cancer development and progression. Krüppel-like factor 5 (KLF5) is a transcription factor that is highly expressed in the proliferating intestinal crypt epithelial cells. Previously, we showed that KLF5 is a mediator of RAS/MAPK and WNT signaling pathways under homeostatic conditions and that it promotes their tumorigenic functions during the development and progression of intestinal adenomas. Recently, using an ultrahigh-throughput scree

SUBMITTER: Ruiz de Sabando A 

PROVIDER: S-EPMC4707060 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature