Top-down characterization data on the speciation of the Candida albicans immunome in candidemia.

ABSTRACT: The characterization of pathogen-specific antigenic proteins at the protein species level is crucial in the development and molecular optimization of novel immunodiagnostics, vaccines or immunotherapeutics for infectious diseases. The major requirements to achieve this molecular level are to obtain 100% sequence coverage and identify all post-translational modifications of each antigenic protein species. In this article, we show nearly complete sequence information for five discrete antigenic species of Candida albicans Tdh3 (glyceraldehyde-3-phosphate dehydrogenase), which have been reported to be differentially recognized both among candidemia patients and between candidemia and control patients. A comprehensive description of the top-down immunoproteomic strategy used for seroprofiling

SUBMITTER: Pitarch A 

PROVIDER: S-EPMC4707175 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature