Trends in Treatment Patterns and Outcomes for Ductal Carcinoma In Situ.

ABSTRACT:

Background

Impact of contemporary treatment of pre-invasive breast cancer (ductal carcinoma in situ [DCIS]) on long-term outcomes remains poorly defined. We aimed to evaluate national treatment trends for DCIS and to determine their impact on disease-specific (DSS) and overall survival (OS).

Methods

The Surveillance, Epidemiology, and End Results (SEER) registry was queried for patients diagnosed with DCIS from 1991 to 2010. Treatment pattern trends were analyzed using Cochran-Armitage trend test. Survival analyses were performed using inverse probability weights (IPW)-adjusted competing risk analyses for DSS and Cox proportional hazard regression for OS. All tests performed were two-sided.

Results

One hundred twenty-one thousand and eighty DCIS patients were identifi

SUBMITTER: Worni M 

PROVIDER: S-EPMC4707192 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature