Impact of KIBRA Polymorphism on Memory Function and the Hippocampus in Older Adults.

ABSTRACT: The single nucleotide polymorphism rs17070145 within the KIBRA gene (kidney and brain expressed protein) has been associated with variations in memory functions and related brain areas. However, previous studies yielded conflicting results, which might be due to divergent sample characteristics or task-specific effects. Therefore, we aimed to determine the impact of KIBRA genotype on learning and memory formation, and volume, microstructural integrity and functional connectivity (FC) of the hippocampus and its subfields in a well-characterized cohort of healthy older adults. One-hundred and forty subjects (72 women, age 50-80) were KIBRA genotyped and memory was tested using the Auditory Verbal Learning Task. Also, subjects underwent structural and resting-state functional magnetic resonan

SUBMITTER: Witte AV 

PROVIDER: S-EPMC4707824 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature