Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.

ABSTRACT:

Background

Risk factors for the development of therapy-related leukemia (TRL), an often lethal late complication of cytotoxic therapy, remain poorly understood and may differ for survivors of different malignancies. Survivors of breast cancer (BC) now account for the majority of TRL cases, making the study of TRL risk factors in this population a priority.

Methods

Subjects with TRL after cytotoxic therapy for a primary BC were identified from the TRL registry at The University of Chicago. Those with an available germline DNA sample were screened with a comprehensive gene panel covering known inherited BC susceptibility genes. Clinical and TRL characteristics of all subjects and those with identified germline mutations were described.

Results

Nineteen of 88 survivors o

SUBMITTER: Churpek JE 

PROVIDER: S-EPMC4707981 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature