Protein profiling of mefloquine resistant Plasmodium falciparum using mass spectrometry-based proteomics.

ABSTRACT: Malaria is a mosquito borne infectious disease caused by protozoa of genus Plasmodium. There are five species of Plasmodium that are found to infect humans. Plasmodium falciparum can cause severe malaria leading to higher morbidity and mortality of malaria than the other four species. Antimalarial resistance is the major obstacle to control malaria. Mefloquine was used in combination with Artesunate for uncomplicated P. falciparum in South East Asia and it has developed and established mefloquine resistance in this region. Here, gel-enhanced liquid chromatography/tandem mass spectrometry (GeLC-MS/MS)-based proteomics and label-free quantification were used to explore the protein profiles of mefloquine-sensitive and -induced resistant P. falciparum. A Thai

SUBMITTER: Reamtong O 

PROVIDER: S-EPMC4708064 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature