Novel methods and technologies for 21st-century clinical trials: a review.

ABSTRACT:

Importance

New technologies are rapidly reshaping health care. However, their effect on drug development to date generally has been limited.

Objectives

To evaluate disease modeling and simulation, alternative study design, novel objective measures, virtual research visits, and enhanced participant engagement and to examine their potential effects as methods and tools on clinical trials.

Evidence review

We conducted a systematic search of relevant terms on PubMed (disease modeling and clinical trials; adaptive design, clinical trials, and neurology; Internet, clinical trials, and neurology; and telemedicine, clinical trials, and neurology), references of previous publications, and our files. The search encompassed articles published from January 1, 2000, through Novemb

SUBMITTER: Dorsey ER 

PROVIDER: S-EPMC4708881 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature