Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting.

ABSTRACT:

Background

Leukocyte telomere length(LTL) has been associated with age, self-reported race/ethnicity, gender, education, and psychosocial factors, including perceived stress, and depression. However, inconsistencies in associations of LTL with disease and other phenotypes exist across studies. Population characteristics, including race/ethnicity, laboratory methods, and statistical approaches in LTL have not been comprehensively studied and could explain inconsistent LTL associations.

Methods

LTL was measured using Southern Blot in 1510 participants from a multi-ethnic, multi-center study combining data from 3 centers with different population characteristics and laboratory processing methods. Main associations between LTL and psychosocial factors and LTL and race/ethnicity

SUBMITTER: Lynch SM 

PROVIDER: S-EPMC4709232 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature