Model-Based Optimisation of Deferoxamine Chelation Therapy.

ABSTRACT:

Purpose

Here we show how a model-based approach may be used to provide further insight into the role of clinical and demographic covariates on the progression of iron overload. The therapeutic effect of deferoxamine is used to illustrate the application of disease modelling as a means to characterising treatment response in individual patients.

Methods

Serum ferritin, demographic characteristics and individual treatment data from clinical routine practice on 27 patients affected by β-thalassaemia major were used for the purposes of this analysis. The time course of serum ferritin was described by a hierarchical nonlinear mixed effects model, in which compliance was parameterised as a covariate factor. Modelling and simulation procedures were implemented in NONMEM (7.2.0).

SUBMITTER: Bellanti F 

PROVIDER: S-EPMC4709373 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature