Network Analysis Shows Novel Molecular Mechanisms of Action for Copper-Based Chemotherapy.

ABSTRACT: The understanding of the mechanisms associated with the action of chemotherapeutic agents is fundamental to assess and account for possible side-effects of such treatments. Casiopeínas have demonstrated a cytotoxic effect by activation of pro-apoptotic processes in malignant cells. Such processes have been proved to activate the apoptotic intrinsic route, as well as cell cycle arrest. Despite this knowledge, the whole mechanism of action of Casiopeínas is yet to be completely understood. In this work we implement a systems biology approach based on two pathway analysis tools (Over-Representation Analysis and Causal Network Analysis) to observe changes in some hallmarks of cancer, induced by this copper-based chemotherapeutic agent in HeLa cell lines. We find that the metabolism of metal io

SUBMITTER: Espinal-Enriquez J 

PROVIDER: S-EPMC4709449 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature