Structural Insights into High Density Lipoprotein: Old Models and New Facts.

ABSTRACT: The physiological link between circulating high density lipoprotein (HDL) levels and cardiovascular disease is well-documented, albeit its intricacies are not well-understood. An improved appreciation of HDL function and overall role in vascular health and disease requires at its foundation a better understanding of the lipoprotein's molecular structure, its formation, and its process of maturation through interactions with various plasma enzymes and cell receptors that intervene along the pathway of reverse cholesterol transport. This review focuses on summarizing recent developments in the field of lipid free apoA-I and HDL structure, with emphasis on new insights revealed by newly published nascent and spherical HDL models constructed by combining low resolution structures obtained from

SUBMITTER: Gogonea V 

PROVIDER: S-EPMC4709926 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature