JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.

ABSTRACT:

Background

While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis in HNSCC is limited. We initially performed the upstream and key nodes analysis together with whole gene microarray analysis characterized by distant metastatic potential in vivo with HNSCC cell lines and identified JunB, a member of the activator protein-1 (AP-1) family, as a key molecule in the regulation of the pathways related to distant metastasis in HNSCC. We have therefore tested the hypothesis that JunB plays a crucial role in distant metastasis in HNSCC.

Methods

To study the role of JunB on metastatic potential of HNSCC, small interfering RNA (siRNA

SUBMITTER: Hyakusoku H 

PROVIDER: S-EPMC4709939 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature