Pangenome-wide and molecular evolution analyses of the Pseudomonas aeruginosa species.

ABSTRACT:

Background

Drug treatments and vaccine designs against the opportunistic human pathogen Pseudomonas aeruginosa have multiple issues, all associated with the diverse genetic traits present in this pathogen, ranging from multi-drug resistant genes to the molecular machinery for the biosynthesis of biofilms. Several candidate vaccines against P. aeruginosa have been developed, which target the outer membrane proteins; however, major issues arise when attempting to establish complete protection against this pathogen due to its presumably genotypic variation at the strain level. To shed light on this concern, we proposed this study to assess the P. aeruginosa pangenome and its molecular evolution across multiple strains.

Results

The P. aeruginosa pangenome was estimated to contai

SUBMITTER: Mosquera-Rendon J 

PROVIDER: S-EPMC4710005 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature