Combining location-and-scale batch effect adjustment with data cleaning by latent factor adjustment.

ABSTRACT:

Background

In the context of high-throughput molecular data analysis it is common that the observations included in a dataset form distinct groups; for example, measured at different times, under different conditions or even in different labs. These groups are generally denoted as batches. Systematic differences between these batches not attributable to the biological signal of interest are denoted as batch effects. If ignored when conducting analyses on the combined data, batch effects can lead to distortions in the results. In this paper we present FAbatch, a general, model-based method for correcting for such batch effects in the case of an analysis involving a binary target variable. It is a combination of two commonly used approaches: location-and-scale adjustment and data cle

SUBMITTER: Hornung R 

PROVIDER: S-EPMC4710051 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature