Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes.

ABSTRACT:

Background

The aim of this study was to investigate the association between serum concentrations of the brain-derived neurotrophic factor (BDNF), platelet reactivity and inflammatory markers, as well as its association with BDNF encoding gene variants in type 2 diabetic patients (T2DM) during acetylsalicylic acid (ASA) therapy.

Material/methods

This retrospective, open-label study enrolled 91 patients. Serum BDNF, genotype variants, hematological, biochemical, and inflammatory markers were measured. Blood samples were taken in the morning 2-3 h after the last ASA dose. The BDNF genotypes for selected variants were analyzed by use of the iPLEX Sequenom assay.

Results

In multivariate linear regression analysis, CADP-CT >74 sec (p<0.001) and sP-selectin concentration (p=

SUBMITTER: Eyileten C 

PROVIDER: S-EPMC4710194 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature